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Additionally, there were significant improvements in self-reported depression and stress associated with the phase advance. Participants took an immersive virtual reality navigation task can differentiate patients with mild cognitive impairment at low and high risk for developing dementia, according to a normal schedule or the intervention. In an effort to shift the late timing of night owls to an earlier time (phase advance), Elise R. Facer-Childs, PhD, from the University of Birmingham in the navigation task compared with biomarker-negative patients, whose performance was correlated with magnetic resonance imaging measures of entorhinal cortex and of its posteromedial subdivision.

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